| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human HBB-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | HBB |
| Gene ID: | 3043 |
| Uniprot ID: | HBB_HUMAN |
| Immunogen Region: | Met1-His147 |
| Immunogen: | Homo sapiens (Human) |
| Post Translational Modifications | Glucose reacts non-enzymatically with the N-terminus of the beta chain to form a stable ketoamine linkage. This takes place slowly and continuously throughout the 120-day life span of the red blood cell. The rate of glycation is increased in patients with diabetes mellitus. S-nitrosylated.a nitric oxide group is first bound to Fe(2+) and then transferred to Cys-94 to allow capture of O(2). Acetylated on Lys-60, Lys-83 and Lys-145 upon aspirin exposure. |
| Function | Involved in oxygen transport from the lung to the various peripheral tissues. LVV-hemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure. Spinorphin: Functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation. |
| Protein Name | Hemoglobin Subunit BetaBeta-GlobinHemoglobin Beta Chain Cleaved Into - Lvv-Hemorphin-7 - Spinorphin |
| Database Links | Reactome: R-HSA-1237044Reactome: R-HSA-1247673Reactome: R-HSA-2168880Reactome: R-HSA-6798695Reactome: R-HSA-9613829Reactome: R-HSA-9615710Reactome: R-HSA-9707564Reactome: R-HSA-9707616Reactome: R-HSA-983231 |
| Alternative Protein Names | Hemoglobin Subunit Beta proteinBeta-Globin proteinHemoglobin Beta Chain Cleaved Into - Lvv-Hemorphin-7 - Spinorphin proteinHBB protein |
Information sourced from Uniprot.org