| Post Translational Modifications | Phosphorylation at Thr-328 is essential for hyaluronan synthase activity. Phosphorylation at Thr-110 is required for transport from ER to Golgi. O-GlcNAcylation at Ser-221 increases the stability of HAS2 and plasma membrane localization. Ubiquitination at Lys-190.this ubiquitination is essential for hyaluronan synthase activity and homo- or hetero-oligomerization. Can also be poly-ubiquitinated. Deubiquitinated by USP17 and USP4. USP17 efficiently removes 'Lys-63'- and 'Lys-48'-linked polyubiquitin chains, whereas USP4 preferentially removes monoubiquitination and, partially, both 'Lys-63'- and 'Lys-48'-linked polyubiquitin chain. |
| Function | Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer (Probable). Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of three isoenzymes responsible for cellular hyaluronan synthesis and it is particularly responsible for the synthesis of high molecular mass hyaluronan. |
| Protein Name | Hyaluronan Synthase 2Hyaluronate Synthase 2Hyaluronic Acid Synthase 2Ha Synthase 2 |
| Database Links | Reactome: R-HSA-2142850 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum MembraneVesicleGolgi Apparatus MembraneLysosomeTravels From Endoplasmic Reticulum (Er)Golgi To Plasma Membrane And Either Back To Endosomes And LysosomesOr Out Into Extracellular VesiclesPost-Translational Modifications Control Has2 Trafficking |
| Alternative Protein Names | Hyaluronan Synthase 2 proteinHyaluronate Synthase 2 proteinHyaluronic Acid Synthase 2 proteinHa Synthase 2 proteinHAS2 protein |
Information sourced from Uniprot.org
