| Post Translational Modifications | Proteolytic cleavage at Gly-23 or Met-27 can give rise to the 50 kDa heavy chain (HC) and cleavage at Arg-313 or Lys-319 can give rise to the 27 kDa light chain (LC). The HC can undergo further proteolytic cleavage giving rise to a 26 kDa fragment. The LC can undergo further proteolytic cleavage at Arg-313 leading to a 17-kDa fragment and at Arg-480 leading to a 8-kDa fragment. |
| Function | Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII (Probable). May function as a tumor suppressor negatively regulating cell proliferation and cell migration. |
| Protein Name | Factor Vii-Activating ProteaseFsapFvii ActivatorHepatocyte Growth Factor Activator-Like ProteinHyaluronan-Binding Protein 2Plasma Hyaluronan-Binding ProteinPhbpPlasma Hyaluronan-Binding Serine ProteasePhbsp Cleaved Into - Factor Vii-Activating Protease 50 Kda N-Terminal Heavy Chain - Factor Vii-Activating Protease 50 Kda N-Terminal Heavy Chain Alternate Form - Factor Vii-Activating Protease 27 Kda C-Terminal Light Chain - Factor Vii-Activating Protease 27 Kda C-Terminal Light Chain Alternate Form |
| Database Links | |
| Cellular Localisation | SecretedSecreted As An Inactive Single-Chain Precursor And Is Then Activated To A Heterodimeric Form |
| Alternative Protein Names | Factor Vii-Activating Protease proteinFsap proteinFvii Activator proteinHepatocyte Growth Factor Activator-Like Protein proteinHyaluronan-Binding Protein 2 proteinPlasma Hyaluronan-Binding Protein proteinPhbp proteinPlasma Hyaluronan-Binding Serine Protease proteinPhbsp Cleaved Into - Factor Vii-Activating Protease 50 Kda N-Terminal Heavy Chain - Factor Vii-Activating Protease 50 Kda N-Terminal Heavy Chain Alternate Form - Factor Vii-Activating Protease 27 Kda C-Terminal Light Chain - Factor Vii-Activating Protease 27 Kda C-Terminal Light Chain Alternate Form proteinHABP2 proteinHGFAL protein |
Information sourced from Uniprot.org
