Human GSDMC protein (Recombinant) (N-His) (STJP007907)

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STJP007907
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human GSDMC-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: GSDMC
Gene ID: 56169
Uniprot ID: GSDMC_HUMAN
Immunogen Region: Lys317-Ala508
Immunogen: Homo sapiens (Human)
Post Translational Modifications Cleavage by CASP8 relieves autoinhibition by releasing the N-terminal moiety (Gasdermin-C, N-terminal) that initiates pyroptosis. The cleavage site is unclear. According to a publication, it takes place after Asp-240 in response to alpha-ketoglutarate. Another paper reports cleavage by CASP8 after Asp-365. Palmitoylated.
Function Gasdermin-C: This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-C, N-terminal) binds to membranes and forms pores, triggering pyroptosis. Gasdermin-C, N-terminal: Pore-forming protein that causes membrane permeabilization and pyroptosis. Produced by the cleavage of gasdermin-C by caspase CASP8 in response to death signals. After cleavage, moves to the plasma membrane where it strongly binds to membrane inner leaflet lipids. Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis.
Protein Name Gasdermin-C
Melanoma-Derived Leucine Zipper-Containing Extranuclear Factor Cleaved Into - Gasdermin-C - N-Terminal
Gsdmc-Nt - Gasdermin-C - C-Terminal
Gsdmc-Ct
Cellular Localisation Gasdermin-C: Cytoplasm
Cytosol
Gasdermin-C
N-Terminal: Cell Membrane
Multi-Pass Membrane Protein
Alternative Protein Names Gasdermin-C protein
Melanoma-Derived Leucine Zipper-Containing Extranuclear Factor Cleaved Into - Gasdermin-C - N-Terminal protein
Gsdmc-Nt - Gasdermin-C - C-Terminal protein
Gsdmc-Ct protein
GSDMC protein
MLZE protein

Information sourced from Uniprot.org