| Applications: | ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.118ng/mL |
| Detection Limit: | 0.312-20ng/mL |
| Short Description: | This GRIN2C Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates or other biological fluids.. |
| Storage Instruction: | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 3 hrs |
| Gene Symbol: | GRIN2C |
| Gene ID: | 2905 |
| Uniprot ID: | NMDE3_HUMAN |
| Immunogen Region: | Ready-To-Use |
| Sample Type: | tissue homogenates or other biological fluids. |
| Tissue Specificity | Mainly expressed in brain with predominant expression is in the cerebellum, also present in the hippocampus, amygdala, caudate nucleus, corpus callosum, subthalamic nuclei and thalamus. Detected in the heart, skeletal muscle and pancreas. |
| Post Translational Modifications | |
| Function | Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+). Participates in synaptic plasticity for learning and memory formation by contributing to the slow phase of excitatory postsynaptic current and long-term synaptic potentiation. Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). NMDARs mediate simultaneously the potasium efflux and the influx of calcium and sodium. Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators. |
| Protein Name | Glutamate Receptor Ionotropic - Nmda 2c Glun2c Glutamate Nmda Receptor Subunit Epsilon-3 N-Methyl D-Aspartate Receptor Subtype 2c Nmdar2c Nr2c |
| Database Links | Reactome: R-HSA-438066 Reactome: R-HSA-6794361 Reactome: R-HSA-8849932 Reactome: R-HSA-9609736 Reactome: R-HSA-9617324 Reactome: R-HSA-9620244 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Postsynaptic Cell Membrane |
| Alternative ELISA Names | Glutamate Receptor Ionotropic - Nmda 2c ELISA kit Glun2c ELISA kit Glutamate Nmda Receptor Subunit Epsilon-3 ELISA kit N-Methyl D-Aspartate Receptor Subtype 2c ELISA kit Nmdar2c ELISA kit Nr2c ELISA kit GRIN2C ELISA kit NMDAR2C ELISA kit |
| output |
Information sourced from Uniprot.org
