| Post Translational Modifications | Multiply phosphorylated in clusters of serines and threonines in the C-terminal tail. Phosphorylation of Ser-300 and Ser-303 is mediated by GRK5 and/or GRK6. |
| Function | G-protein coupled receptor that binds to several ligands including the tryptophan metabolite kynurenic acid (KYNA), lysophosphatidic acid (LPA) or 5-hydroxyindoleacetic acid (5-HIAA) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Plays a role in neutrophil recruitment to sites of inflammation and bacterial clearance through the major serotonin metabolite 5-HIAA that acts as a physiological ligand. Stimulates lipid metabolism, thermogenic, and anti-inflammatory gene expression in adipose tissue once activated by kynurenic acid. In macrophages, activation by lysophosphatidic acid promotes GPR35-induced signaling with a distinct transcriptional profile characterized by TNF production associated with ERK and NF-kappa-B activation. In turn, induces chemotaxis of macrophages. |
| Protein Name | G-Protein Coupled Receptor 35Kynurenic Acid ReceptorKyna Receptor |
| Database Links | Reactome: R-HSA-373076 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinInternalized To The Cytoplasm After Exposure To Kynurenic Acid |
| Alternative Protein Names | G-Protein Coupled Receptor 35 proteinKynurenic Acid Receptor proteinKyna Receptor proteinGPR35 protein |
Information sourced from Uniprot.org
