| Post Translational Modifications | Glycosylated. Phosphorylated. |
| Function | Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane.this ligand-dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Also plays a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport. |
| Protein Name | G-Protein Coupled Receptor 143Ocular Albinism Type 1 Protein |
| Database Links | Reactome: R-HSA-375280Reactome: R-HSA-416476Reactome: R-HSA-9824585 |
| Cellular Localisation | Melanosome MembraneMulti-Pass Membrane ProteinLysosome MembraneApical Cell MembraneDistributed Throughout The Endo-Melanosomal System But Most Of Endogenous Protein Is Localized In Unpigmented Stage Ii MelanosomesIts Expression On The Apical Cell Membrane Is Sensitive To Tyrosine |
| Alternative Protein Names | G-Protein Coupled Receptor 143 proteinOcular Albinism Type 1 Protein proteinGPR143 proteinOA1 protein |
Information sourced from Uniprot.org
