| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human GPC1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | GPC1 |
| Gene ID: | 2817 |
| Uniprot ID: | GPC1_HUMAN |
| Immunogen Region: | Glu208-Ser530 |
| Immunogen: | Homo sapiens (Human) |
| Function | Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination. May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling. |
| Protein Name | Glypican-1 Cleaved Into - Secreted Glypican-1 |
| Database Links | Reactome: R-HSA-1971475Reactome: R-HSA-2022928Reactome: R-HSA-2024096Reactome: R-HSA-202733Reactome: R-HSA-3560783Reactome: R-HSA-3560801Reactome: R-HSA-3656237Reactome: R-HSA-3656253Reactome: R-HSA-376176Reactome: R-HSA-4420332Reactome: R-HSA-9694614Reactome: R-HSA-975634Reactome: R-HSA-9820960Reactome: R-HSA-9833110 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorExtracellular SideEndosomeS-Nitrosylated Form Recycled In EndosomesLocalizes To Cav1-Containing Vesicles Close To The Cell SurfaceCleavage Of Heparan Sulfate Side Chains Takes Place Mainly In Late EndosomesAssociates With Both Forms Of Prnp In Lipid RaftsColocalizes With App In Perinuclear Compartments And With Cp In Intracellular CompartmentsAssociates With Fibrillar App Amyloid-Beta Peptides In Lipid Rafts In Alzheimer Disease BrainsSecreted Glypican-1: SecretedExtracellular Space |
| Alternative Protein Names | Glypican-1 Cleaved Into - Secreted Glypican-1 proteinGPC1 protein |
Information sourced from Uniprot.org
