| Function | Key structural protein of the Golgi apparatus. The membrane cisternae of the Golgi apparatus adhere to each other to form stacks, which are aligned side by side to form the Golgi ribbon. Acting in concert with GORASP1/GRASP65, is required for the formation and maintenance of the Golgi ribbon, and may be dispensable for the formation of stacks. However, other studies suggest that GORASP2 plays a role in the assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after breakdown during mitosis and meiosis. May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA. Required for normal acrosome formation during spermiogenesis and normal male fertility, probably by promoting colocalization of JAM2 and JAM3 at contact sites between germ cells and Sertoli cells. Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane. |
| Protein Name | Golgi Reassembly-Stacking Protein 2Grs2Golgi Phosphoprotein 6Golph6Golgi Reassembly-Stacking Protein Of 55 KdaGrasp55P59 |
| Database Links | Reactome: R-HSA-162658 |
| Cellular Localisation | Golgi Apparatus MembraneLipid-AnchorEndoplasmic Reticulum MembraneGolgi ApparatusDetected In The Intermediate GolgiMembrane-AssociatedEr Stress Triggers Its Relocalization From Golgi To Er Membrane |
| Alternative Protein Names | Golgi Reassembly-Stacking Protein 2 proteinGrs2 proteinGolgi Phosphoprotein 6 proteinGolph6 proteinGolgi Reassembly-Stacking Protein Of 55 Kda proteinGrasp55 proteinP59 proteinGORASP2 proteinGOLPH6 protein |
Information sourced from Uniprot.org
