Human GLS protein (Recombinant) (N-His) (STJP003415)

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STJP003415
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human GLS-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: GLS
Gene ID: 2744
Uniprot ID: GLSK_HUMAN
Immunogen Region: Ile221-Leu533
Immunogen: Homo sapiens (Human)
Post Translational Modifications Synthesized as a 74-kDa cytosolic precursor which is proteolytically processed by the mitochondrial-processing peptidase (MPP) via a 72-kDa intermediate to yield the mature mitochondrial 68- and 65-kDa subunits.
Function Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate, the main excitatory neurotransmitter in the brain. Isoform 2: Lacks catalytic activity.
Protein Name Glutaminase Kidney Isoform - Mitochondrial
Gls
K-Glutaminase
L-Glutamine Amidohydrolase Cleaved Into - Glutaminase Kidney Isoform - Mitochondrial 68 Kda Chain - Glutaminase Kidney Isoform - Mitochondrial 65 Kda Chain
Database Links Reactome: R-HSA-210500
Reactome: R-HSA-5628897
Reactome: R-HSA-8964539
Cellular Localisation Isoform 1: Mitochondrion
Cytoplasm
Cytosol
The 74-Kda Cytosolic Precursor Is Translocated Into The Mitochondria And Processed Via A 72-Kda Intermediate To Yield The Mature 68- And 65-Kda Subunits
Isoform 3: Mitochondrion
Glutaminase Kidney Isoform
Mitochondrial 68 Kda Chain: Mitochondrion Matrix
Produced By The Proteolytic Processing Of The 74-Kda Cytosolic Precursor
Mitochondrial 65 Kda Chain: Mitochondrion Matrix
Alternative Protein Names Glutaminase Kidney Isoform - Mitochondrial protein
Gls protein
K-Glutaminase protein
L-Glutamine Amidohydrolase Cleaved Into - Glutaminase Kidney Isoform - Mitochondrial 68 Kda Chain - Glutaminase Kidney Isoform - Mitochondrial 65 Kda Chain protein
GLS protein
GLS1 protein
KIAA0838 protein

Information sourced from Uniprot.org

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