Human GGT5 protein (Recombinant) (N-His) (STJP004640)

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STJP004640
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Host: E.coli
Applications: ELISA/Immunogen/SDS-PAGE/WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human GGT5-N-His protein was developed from e.coli for the region N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Dilution Range: Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: GGT5
Gene ID: 2687
Uniprot ID: GGT5_HUMAN
Immunogen Region: Thr388-Tyr586
Immunogen: Homo sapiens (Human)
Post Translational Modifications Cleaved by autocatalysis into a large and a small subunit. Glycosylated.
Function Cleaves the gamma-glutamyl bond of extracellular glutathione tripeptide (gamma-Glu-Cys-Gly) and certain glutathione conjugates. Hydrolyzes glutathione releasing L-Glu and Cys-Gly dipeptide which is further metabolized to maintain extracellular cysteine levels but also to provide cysteine necessary for intracellular glutathione synthesis. Among glutathione-S-conjugates metabolizes leukotriene C4 (LTC4) and S-geranylgeranyl-glutathione (GGG), but is inactive toward gamma-glutamyl leucine. Converts extracellular LTC4 to LTD4 during acute inflammatory response. Acts as a negative regulator of GGG bioactivity. GGT5 (via GGG catabolism) and ABCC1 (via extracellular transport) establish GGG gradients within lymphoid tissues to position P2RY8-positive lymphocytes at germinal centers in lymphoid follicles and restrict their chemotactic transmigration from blood vessels to bone marrow parenchyma. The transpeptidation reaction, i.e. the transfer of gamma-glutamyl moiety to an acceptor molecule to yield a new gamma-glutamyl compound requires high concentration of dipeptide acceptor and is considered nonphysiological.
Protein Name Glutathione Hydrolase 5 Proenzyme
Gamma-Glutamyl Transpeptidase-Related Enzyme
Ggt-Rel
Gamma-Glutamyltransferase 5
Ggt 5
Gamma-Glutamyltransferase-Like Activity 1
Gamma-Glutamyltranspeptidase 5
Leukotriene-C4 Hydrolase Cleaved Into - Glutathione Hydrolase 5 Heavy Chain - Glutathione Hydrolase 5 Light Chain
Database Links Reactome: R-HSA-174403
Reactome: R-HSA-2142691
Reactome: R-HSA-5423646
Reactome: R-HSA-9664535
Reactome: R-HSA-9753281
Cellular Localisation Membrane
Single-Pass Type Ii Membrane Protein
Alternative Protein Names Glutathione Hydrolase 5 Proenzyme protein
Gamma-Glutamyl Transpeptidase-Related Enzyme protein
Ggt-Rel protein
Gamma-Glutamyltransferase 5 protein
Ggt 5 protein
Gamma-Glutamyltransferase-Like Activity 1 protein
Gamma-Glutamyltranspeptidase 5 protein
Leukotriene-C4 Hydrolase Cleaved Into - Glutathione Hydrolase 5 Heavy Chain - Glutathione Hydrolase 5 Light Chain protein
GGT5 protein
GGTLA1 protein

Information sourced from Uniprot.org

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