Tissue Specificity | |
Post Translational Modifications | |
Function | Coreceptor for GDNF, a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. GDNF-binding leads to autophosphorylation and activation of the RET receptor. |
Protein Name | Gdnf Family Receptor Alpha-1Gdnf Receptor Alpha-1Gdnfr-Alpha-1Gfr-Alpha-1Ret Ligand 1Tgf-Beta-Related Neurotrophic Factor Receptor 1 |
Database Links | Reactome: R-HSA-419037Reactome: R-HSA-5673001Reactome: R-HSA-8853659Reactome: R-HSA-9830674 |
Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorGolgi ApparatusTrans-Golgi NetworkEndosomeMultivesicular BodyLocalizes Mainly To The Plasma MembraneIn The Presence Of Sorl1Shifts To Vesicular StructuresIncluding Trans-Golgi NetworkEndosomes And Multivesicular Bodies |
Alternative ELISA Names | Gdnf Family Receptor Alpha-1 ELISA kitGdnf Receptor Alpha-1 ELISA kitGdnfr-Alpha-1 ELISA kitGfr-Alpha-1 ELISA kitRet Ligand 1 ELISA kitTgf-Beta-Related Neurotrophic Factor Receptor 1 ELISA kitGFRA1 ELISA kitGDNFRA ELISA kitRETL1 ELISA kitTRNR1 ELISA kit |
output | |
Information sourced from Uniprot.org