| Host: | E.coli |
| Applications: | ELISA/WB |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Active-Human GDNF-Tag free protein was developed from e.coli and has a target region of Tag free. For use in research applications. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilized from a 0.2 Mu m filtered solution in 20 mM PB, 150 mM NaCl, pH 7.4. |
| Dilution Range: | Reconstitute in sterile water for a stock solution. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin: | < 0.01 EU/µg as determined by LAL test. |
| Gene Symbol: | GDNF |
| Gene ID: | 2668 |
| Uniprot ID: | GDNF_HUMAN |
| Immunogen Region: | Ser78-Ile211 |
| Immunogen: | Homo sapiens (Human) |
| Function | Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. Acts by binding to its coreceptor, GFRA1, leading to autophosphorylation and activation of the RET receptor. Involved in the development of the neural crest. |
| Protein Name | Glial Cell Line-Derived Neurotrophic FactorHgdnfAstrocyte-Derived Trophic FactorAtf |
| Database Links | Reactome: R-HSA-419037Reactome: R-HSA-5673001Reactome: R-HSA-8853659Reactome: R-HSA-9830674 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Glial Cell Line-Derived Neurotrophic Factor proteinHgdnf proteinAstrocyte-Derived Trophic Factor proteinAtf proteinGDNF protein |
Information sourced from Uniprot.org