Human GDF5 protein (Recombinant) (N-His) (STJP004732)

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STJP004732
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human GDF5-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: GDF5
Gene ID: 8200
Uniprot ID: GDF5_HUMAN
Immunogen Region: Ala382-Arg501
Immunogen: Homo sapiens (Human)
Function Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction. Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG. Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes.
Protein Name Growth/Differentiation Factor 5
Gdf-5
Bone Morphogenetic Protein 14
Bmp-14
Cartilage-Derived Morphogenetic Protein 1
Cdmp-1
Lipopolysaccharide-Associated Protein 4
Lap-4
Lps-Associated Protein 4
Radotermin
Database Links Reactome: R-HSA-2129379
Cellular Localisation Secreted
Cell Membrane
Alternative Protein Names Growth/Differentiation Factor 5 protein
Gdf-5 protein
Bone Morphogenetic Protein 14 protein
Bmp-14 protein
Cartilage-Derived Morphogenetic Protein 1 protein
Cdmp-1 protein
Lipopolysaccharide-Associated Protein 4 protein
Lap-4 protein
Lps-Associated Protein 4 protein
Radotermin protein
GDF5 protein
BMP14 protein
CDMP1 protein

Information sourced from Uniprot.org

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