Human GCSH protein (Recombinant) (His-Tag) (STJP017405)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human GCSH-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol, 1mM DTT, 0.15M NaCl. |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GCSH |
| Gene ID | 2653 |
| Uniprot ID | GCSH_HUMAN |
| Accession Number | NP_004474 |
| Immunogen | Human |
| Immunogen Region | 49-173aa |
| Immunogen Sequence |
Additional Info
| Function | The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST). Has a pivotal role in the lipoylation of enzymes involved in cellular energetics such as the mitochondrial dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex (DLAT), and the mitochondrial dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex (DLST). |
| Protein Name | Glycine Cleavage System H Protein - MitochondrialLipoic Acid-Containing Protein |
| Database Links | Reactome: R-HSA-6783984Reactome: R-HSA-9857492 |
| Cellular Localisation | Mitochondrion |
| Alternative Protein Names | Glycine Cleavage System H Protein - Mitochondrial proteinLipoic Acid-Containing Protein proteinGCSH protein |
Information sourced from Uniprot.org