| Short Description : | Recombinant-Human GCH1-N-His protein was developed from e.coli and has a target region of N-His. For use in research applications. |
| Applications: | ELISA/WB |
| Host: | E.coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Dilution Range: | Reconstitute in sterile water for a stock solution. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin: | Please contact us for this information. |
| Gene Symbol: | GCH1 |
| Gene ID: | 2643 |
| Uniprot ID: | GCH1_HUMAN |
| Immunogen: | Homo sapiens (Human) |
| Immunogen Region: | Ser60-Ser250 |
| Post Translational Modifications | Phosphorylated by casein kinase II at Ser-81 in HAECs during oscillatory shear stress.phosphorylation at Ser-81 results in increased enzyme activity. |
| Function | Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown. |
| Protein Name | Gtp Cyclohydrolase 1Gtp Cyclohydrolase IGtp-Ch-I |
| Database Links | Reactome: R-HSA-1474151 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Protein Names | Gtp Cyclohydrolase 1 proteinGtp Cyclohydrolase I proteinGtp-Ch-I proteinGCH1 proteinDYT5 proteinGCH protein |
Information sourced from Uniprot.org