| Function | Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens. Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP. Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria. Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol. Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome. Confers protection to the protozoan pathogen Toxoplasma gondii. Independently of its GTPase activity, acts as an inhibitor of various viruses infectivity, such as HIV-1, Zika and influenza A viruses, by inhibiting FURIN-mediated maturation of viral envelope proteins. |
| Protein Name | Guanylate-Binding Protein 2Gtp-Binding Protein 2Gbp-2Hugbp-2Guanine Nucleotide-Binding Protein 2Interferon-Induced Guanylate-Binding Protein 2 |
| Database Links | Reactome: R-HSA-877300Reactome: R-HSA-909733 |
| Cellular Localisation | Cytoplasmic Vesicle MembraneLipid-AnchorGolgi Apparatus MembraneCytoplasmPerinuclear RegionGbp2-Gbp5 Dimers Localize To The Golgi Apparatus |
| Alternative Protein Names | Guanylate-Binding Protein 2 proteinGtp-Binding Protein 2 proteinGbp-2 proteinHugbp-2 proteinGuanine Nucleotide-Binding Protein 2 proteinInterferon-Induced Guanylate-Binding Protein 2 proteinGBP2 protein |
Information sourced from Uniprot.org
