Human GATA1 protein (Recombinant) (N-His-SUMO) (STJP008315)

SKU:
STJP008315
$443.48 - $1,940.63
Free Shipping
Processing The item has been added
Enquire For Bulk Order

Covered by St John's Laboratory Guarantee

Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human GATA1-N-His-SUMO protein was developed from e. coli and has a target region of N-His-SUMO. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: GATA1
Gene ID: 2623
Uniprot ID: GATA1_HUMAN
Immunogen Region: Ala211-Asp300
Immunogen: Homo sapiens (Human)
Post Translational Modifications Highly phosphorylated on serine residues. Phosphorylation on Ser-310 is enhanced on erythroid differentiation. Phosphorylation on Ser-142 promotes sumoylation on Lys-137. Sumoylation on Lys-137 is enhanced by phosphorylation on Ser-142 and by interaction with PIAS4. Sumoylation with SUMO1 has no effect on transcriptional activity. Acetylated at 2 conserved lysine-rich motifs by CREBBP in vitro. Acetylation does not affect DNA-binding in vitro but is essential to induce erythroid differentiation and for binding chromatin in vivo. Acetylated on Lys-233, Lys-245 Lys-246 by EP300.
Function Transcriptional activator or repressor which serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-ATGATAAG-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS.
Protein Name Erythroid Transcription Factor
Eryf1
Gata-Binding Factor 1
Gata-1
Gf-1
Nf-E1 Dna-Binding Protein
Database Links Reactome: R-HSA-8936459
Reactome: R-HSA-8939236
Reactome: R-HSA-983231
Cellular Localisation Nucleus
Alternative Protein Names Erythroid Transcription Factor protein
Eryf1 protein
Gata-Binding Factor 1 protein
Gata-1 protein
Gf-1 protein
Nf-E1 Dna-Binding Protein protein
GATA1 protein
ERYF1 protein
GF1 protein

Information sourced from Uniprot.org

Related Products

Model Name Host Clonality Reactivity Application
STJP003590 Human APOA2 protein (Recombinant) (N-His-SUMO) (STJP003590) E. coli
STJP003879 Human FGF2 protein (Recombinant) (N-His-SUMO) (STJP003879) E. coli
STJP004668 Human GDNF protein (Recombinant) (N-His-SUMO) (STJP004668) E. coli
STJP007322 Human CD81 protein (Recombinant) (N-His-SUMO) (STJP007322) E. coli
STJP007330 Human HNRNPH1 protein (Recombinant) (N-His-SUMO) (STJP007330) E. coli

Related Products

!