| Host: |
HEK293 cells |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human GAS-6-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications. |
| Formulation: |
Supplied as a 0.22 Mu m filtered solution in 20mM Tris, 500mM NaCl (pH 8.5). |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity: |
Immobilized Human GAS6, His Tag at 5 Mu g/ml (100 Mu l/well) on the plate. Dose response curve for Human Axl with the EC50 of 7.5ng/ml determined by ELISA. |
| Gene Symbol: |
GAS6 |
| Gene ID: |
2621 |
| Uniprot ID: |
GAS6_HUMAN |
| Immunogen Region: |
Ala49-Ala678 |
| Immunogen: |
Recombinant Human GAS-6 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala49-Ala678) of human GAS-6 (Accession #NP_000811.1) fused with a 6×His tag at the C-terminus. |
| Post Translational Modifications | Isoform 2: Proteolytically processed after secretion to yield a N-terminal 36 kDa protein and a C-terminal 50 kDa protein including the laminin G-like domains which activates AXL. Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium. |
| Function | Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. (Microbial infection) Can bridge virus envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry by apoptotic mimicry. Plays a role in Dengue cell entry by apoptotic mimicry. Plays a role in Vaccinia virus cell entry by apoptotic mimicry. Plays a role in ebolavirus and marburgvirus cell entry by apoptotic mimicry. |
| Protein Name | Growth Arrest-Specific Protein 6Gas-6Axl Receptor Tyrosine Kinase Ligand |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-159740Reactome: R-HSA-159763Reactome: R-HSA-159782Reactome: R-HSA-202733Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Growth Arrest-Specific Protein 6 proteinGas-6 proteinAxl Receptor Tyrosine Kinase Ligand proteinGAS6 proteinAXLLG protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
