• Biotinylated Human GARP&Latent TGF beta 1 Complex on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
  • The purity of Biotinyated Human GARP&Latent TGF beta 1 Complex is greater than 95% as determined by SEC-HPLC.
  • Immobilized Anti-GARP&Latent TGF beta 1 Antibody, hFc Tag at 5 Mu g/ml (100 Mu l/well) on the plate. Dose response curve for Biotinylated Human GARP&Latent TGF Beta 1 Complex, His Tag with the EC50 of 44. 0ng/ml determined by ELISA.

Human GARP&Latent TGF beta 1 Complex protein (Recombinant) (C-His-Avi) {Biotin} (STJP001759)

SKU:
STJP001759

£775.50 - £2,435.50
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Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human GARP&Latent TGF beta 1 Complex-C-His-Avi protein was developed from hek293 and has a target region of C-His-Avi. For use in research applications.
Conjugation: Biotin
Formulation: Lyophilised from 0.2 µm filtered PBS solution pH7.4.
Dilution Range: Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM
Storage Instruction: The lyophilized protein is stable for at least 1 year from date of receipt at-20°C.
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).
Gene Symbol: LRRC32
Gene ID: 2615
Uniprot ID: LRC32_HUMAN
Immunogen Region: His20-Leu628 (GARP) & Leu30-Ser390 (Latent TGF beta 1)
Immunogen: DNA sequence encoding Human GARP&Latent TGF beta 1 Complex including a C-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology.
Function Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta. Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs). Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3).
Protein Name Transforming Growth Factor Beta Activator Lrrc32
Garpin
Glycoprotein A Repetitions Predominant
Garp
Leucine-Rich Repeat-Containing Protein 32
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cell Surface
Alternative Protein Names Transforming Growth Factor Beta Activator Lrrc32 protein
Garpin protein
Glycoprotein A Repetitions Predominant protein
Garp protein
Leucine-Rich Repeat-Containing Protein 32 protein
LRRC32 protein
D11S833E protein

Information sourced from Uniprot.org

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