| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of 20mM HEPES, 150mM NaCl, 1mM TCEP, pH 8.0. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 0.1 EU/Mu g of the protein by LAL method. |
| Gene Symbol: | GGH |
| Gene ID: | 8836 |
| Uniprot ID: | GGH_HUMAN |
| Immunogen Region: | Arg25-Asp318 |
| Immunogen: | Recombinant Human Gamma-glutamyl hydrolase/GGH Protein is produced by E. coli expression system. The target protein is expressed with sequence (Arg25-Asp318) of Human Gamma-glutamyl hydrolase/GGH (Accession #NP_003869.1) fused with a His tag at the N |
| Immunogen Sequence: | PARTAPARVPTLAVPAISLP DDVRRRLKDLERDSLTEKEC VKEKLNLLHEFLQTEIKNQL CDLETKLRKEELSEEGYLAK VKSLLNKDLSLENGAHAYNR EVNGRLENGNQARSEARRVG MADANSPPKPLSKPRTPRRS KSDGEAKRSRDPPASASQVT GIRAEPSPSPRITRKSTRQT TITSHFAKGPAKRKPQEESE RAKSDESIKEEDKDQDEKRR RVTSRERVARPLPAEEPER |
| Function | Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates. |
| Protein Name | Gamma-Glutamyl HydrolaseConjugaseGhGamma-Glu-X Carboxypeptidase |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | SecretedExtracellular SpaceLysosomeMelanosomeWhile Its Intracellular Location Is Primarily The LysosomeMost Of The Enzyme Activity Is SecretedIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv |
| Alternative Protein Names | Gamma-Glutamyl Hydrolase proteinConjugase proteinGh proteinGamma-Glu-X Carboxypeptidase proteinGGH protein |
Information sourced from Uniprot.org