Human GABRA2 protein (Recombinant) (N-GST) (STJP004775)

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STJP004775
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human GABRA2-N-GST protein was developed from e. coli and has a target region of N-GST. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: GABRA2
Gene ID: 2555
Uniprot ID: GBRA2_HUMAN
Immunogen Region: Phe42-Ile250
Immunogen: Homo sapiens (Human)
Function Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interfaces. When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission. The alpha-2 subunit exhibits synaptogenic activity together with beta-2 and very little to no activity together with beta-3, the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation.
Protein Name Gamma-Aminobutyric Acid Receptor Subunit Alpha-2
Gaba(A Receptor Subunit Alpha-2
Gabaar Subunit Alpha-2
Database Links Reactome: R-HSA-977443
Cellular Localisation Postsynaptic Cell Membrane
Multi-Pass Membrane Protein
Cell Membrane
Cytoplasmic Vesicle Membrane
Cell Projection
Dendrite
Alternative Protein Names Gamma-Aminobutyric Acid Receptor Subunit Alpha-2 protein
Gaba(A Receptor Subunit Alpha-2 protein
Gabaar Subunit Alpha-2 protein
GABRA2 protein

Information sourced from Uniprot.org

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