Human FUT4 protein (Recombinant) (N-His) (STJP004339)

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STJP004339
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human FUT4-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: FUT4
Gene ID: 2526
Uniprot ID: FUT4_HUMAN
Immunogen Region: Asp264-Thr497
Immunogen: Homo sapiens (Human)
Function Isoform Short: Catalyzes alpha(1->3) linkage of fucosyl moiety transferred from GDP-beta-L-fucose to N-acetyl glucosamine (GlcNAc) within type 2 lactosamine (LacNAc, Gal-beta(1->4)GlcNAc) glycan attached to N- or O-linked glycoproteins. Robustly fucosylates nonsialylated distal LacNAc unit of the polylactosamine chain to form Lewis X antigen (CD15), a glycan determinant known to mediate important cellular functions in development and immunity. Fucosylates with lower efficiency sialylated LacNAc acceptors to form sialyl Lewis X and 6-sulfo sialyl Lewis X determinants that serve as recognition epitopes for C-type lectins. Together with FUT7 contributes to SELE, SELL and SELP selectin ligand biosynthesis and selectin-dependent lymphocyte homing, leukocyte migration and blood leukocyte homeostasis. In a cell type specific manner, may also fucosylate the internal LacNAc unit of the polylactosamine chain to form VIM-2 antigen that serves as recognition epitope for SELE. Isoform Long: Does not generate Lewis X antigens.
Protein Name Alpha-(1 -3-Fucosyltransferase 4
4-Galactosyl-N-Acetylglucosaminide 3-Alpha-L-Fucosyltransferase
Elam-1 Ligand Fucosyltransferase
Fucosyltransferase 4
Fucosyltransferase Iv
Fuc-Tiv
Fuct-Iv
Galactoside 3-L-Fucosyltransferase
Database Links Reactome: R-HSA-9037629
Cellular Localisation Golgi Apparatus
Golgi Stack Membrane
Single-Pass Type Ii Membrane Protein
Membrane-Bound Form In Trans Cisternae Of Golgi
Alternative Protein Names Alpha-(1 -3-Fucosyltransferase 4 protein
4-Galactosyl-N-Acetylglucosaminide 3-Alpha-L-Fucosyltransferase protein
Elam-1 Ligand Fucosyltransferase protein
Fucosyltransferase 4 protein
Fucosyltransferase Iv protein
Fuc-Tiv protein
Fuct-Iv protein
Galactoside 3-L-Fucosyltransferase protein
FUT4 protein
ELFT protein
FCT3A protein

Information sourced from Uniprot.org

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