| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human FRS2-N-His-SUMO protein was developed from e. coli and has a target region of N-His-SUMO. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | FRS2 |
| Gene ID: | 10818 |
| Uniprot ID: | FRS2_HUMAN |
| Immunogen Region: | Asn19-Ser109 |
| Immunogen: | Homo sapiens (Human) |
| Post Translational Modifications | Phosphorylated by ULK2 in vitro. Phosphorylated on tyrosine residues upon stimulation by NGF or FGF2. Phosphorylated on tyrosine residues by activated ALK and FGFR1. Phosphorylated on tyrosine residues upon activation of FGFR2 and FGFR3. Phosphorylated on threonine residues by MAP kinases.this inhibits tyrosine phosphorylation, and thereby down-regulates FRS2-mediated activation of MAP kinases. Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination. |
| Function | Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. |
| Protein Name | Fibroblast Growth Factor Receptor Substrate 2Fgfr Substrate 2Fgfr-Signaling Adaptor SntSuc1-Associated Neurotrophic Factor Target 1Snt-1 |
| Database Links | Reactome: R-HSA-109704Reactome: R-HSA-1257604Reactome: R-HSA-170968Reactome: R-HSA-201556Reactome: R-HSA-2219530Reactome: R-HSA-5654689Reactome: R-HSA-5654693Reactome: R-HSA-5654695Reactome: R-HSA-5654700Reactome: R-HSA-5654706Reactome: R-HSA-5654710Reactome: R-HSA-5654712Reactome: R-HSA-5654720Reactome: R-HSA-5654726Reactome: R-HSA-5654727Reactome: R-HSA-5654732Reactome: R-HSA-5654733Reactome: R-HSA-5655253Reactome: R-HSA-5655291Reactome: R-HSA-5655302Reactome: R-HSA-5655332Reactome: R-HSA-5673001Reactome: R-HSA-6811558Reactome: R-HSA-8853659Reactome: R-HSA-9028731Reactome: R-HSA-9696270Reactome: R-HSA-9696273Reactome: R-HSA-9725370 |
| Cellular Localisation | Endomembrane SystemCytoplasmicMembrane-Bound |
| Alternative Protein Names | Fibroblast Growth Factor Receptor Substrate 2 proteinFgfr Substrate 2 proteinFgfr-Signaling Adaptor Snt proteinSuc1-Associated Neurotrophic Factor Target 1 proteinSnt-1 proteinFRS2 protein |
Information sourced from Uniprot.org