| Post Translational Modifications | Phosphorylated in M (mitotic) phase. Phosphorylation by the checkpoint kinase CHEK2 in response to DNA damage increases the FOXM1 protein stability probably stimulating the transcription of genes involved in DNA repair. Phosphorylated by CDK1 in late S and G2 phases, creating docking sites for the POLO box domains of PLK1. Subsequently, PLK1 binds and phosphorylates FOXM1, leading to activation of transcriptional activity and subsequent enhanced expression of key mitotic regulators. Phosphorylated by GSK3B leading to ubiquitination and proteasomal degradation. Ubiquitinated in a FBXW7-dependent manner leading to proteasomal degradation. |
| Function | Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Also plays a role in DNA break repair, participating in the DNA damage checkpoint response. Promotes transcription of PHB2. |
| Protein Name | Forkhead Box Protein M1Forkhead-Related Protein Fkhl16Hepatocyte Nuclear Factor 3 Forkhead Homolog 11Hfh-11Hnf-3/Fork-Head Homolog 11M-Phase Phosphoprotein 2Mpm-2 Reactive Phosphoprotein 2Transcription Factor TridentWinged-Helix Factor From Ins-1 Cells |
| Database Links | Reactome: R-HSA-156711Reactome: R-HSA-69273Reactome: R-HSA-9725371 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Forkhead Box Protein M1 proteinForkhead-Related Protein Fkhl16 proteinHepatocyte Nuclear Factor 3 Forkhead Homolog 11 proteinHfh-11 proteinHnf-3/Fork-Head Homolog 11 proteinM-Phase Phosphoprotein 2 proteinMpm-2 Reactive Phosphoprotein 2 proteinTranscription Factor Trident proteinWinged-Helix Factor From Ins-1 Cells proteinFOXM1 proteinFKHL16 proteinHFH11 proteinMPP2 proteinWIN protein |
Information sourced from Uniprot.org
