Human FOXL2 protein (Recombinant) (N-His-SUMO & C-Strep) (STJP008262)

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STJP008262
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human FOXL2-N-His-SUMO & C-Strep protein was developed from e. coli and has a target region of N-His-SUMO & C-Strep. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: FOXL2
Gene ID: 668
Uniprot ID: FOXL2_HUMAN
Immunogen Region: Ser58-Gly141
Immunogen: Homo sapiens (Human)
Post Translational Modifications Sumoylated with SUMO1.sumoylation is required for transcriptional repression activity.
Function Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9. Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen. Is a regulator of CYP19 expression. Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element. Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2.
Protein Name Forkhead Box Protein L2
Database Links Reactome: R-HSA-3232118
Cellular Localisation Nucleus
Alternative Protein Names Forkhead Box Protein L2 protein
FOXL2 protein

Information sourced from Uniprot.org

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