| Function | Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis.binds to and activates transcription from the G6PC1 promoter. Binds to the CYP3A4 promoter and activates its transcription in cooperation with CEBPA. Binds to the CYP3A7 promoter together with members of the CTF/NF-I family. Involved in regulation of neuronal-specific transcription. May be involved in regulation of spermatogenesis. |
| Protein Name | Hepatocyte Nuclear Factor 3-GammaHnf-3-GammaHnf-3gFork Head-Related Protein Fkh H3Forkhead Box Protein A3Transcription Factor 3gTcf-3g |
| Database Links | Reactome: R-HSA-210745 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Hepatocyte Nuclear Factor 3-Gamma proteinHnf-3-Gamma proteinHnf-3g proteinFork Head-Related Protein Fkh H3 proteinForkhead Box Protein A3 proteinTranscription Factor 3g proteinTcf-3g proteinFOXA3 proteinHNF3G proteinTCF3G protein |
Information sourced from Uniprot.org
