| Host: | Mammalian Cells |
| Applications: | ELISA/WB |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Active-Human FNDC5-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Dilution Range: | Reconstitute in sterile water for a stock solution. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin: | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity: | Measured by its ability to induce p38 MAPK activation in mouse embryonic fibroblast adipose-like cells (3T3‑L1). 1 Mu g/mL of recombinant human FNDC5/Irisin can effectively induce p38 MAPK activation. |
| Gene Symbol: | FNDC5 |
| Gene ID: | 252995 |
| Uniprot ID: | FNDC5_HUMAN |
| Immunogen Region: | Gly32-Leu143 |
| Immunogen: | Homo sapiens (Human) |
| Post Translational Modifications | The extracellular domain is cleaved and released from the cell membrane. N-Glycosylated. |
| Function | Irisin: Mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA. |
| Protein Name | Fibronectin Type Iii Domain-Containing Protein 5Fibronectin Type Iii Repeat-Containing Protein 2 Cleaved Into - Irisin |
| Database Links | |
| Cellular Localisation | Fibronectin Type Iii Domain-Containing Protein 5: Cell MembraneSingle-Pass Membrane ProteinPeroxisome MembraneImported Into Peroxisomes Through The Pex5 Receptor PathwayIrisin: SecretedDetected In Plasma Following Endurance Exercise |
| Alternative Protein Names | Fibronectin Type Iii Domain-Containing Protein 5 proteinFibronectin Type Iii Repeat-Containing Protein 2 Cleaved Into - Irisin proteinFNDC5 proteinFRCP2 protein |
Information sourced from Uniprot.org
