| Host: |
HEK293 cells |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human Flt4 ligand/VEGF-C-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity: |
Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human VEGF-C at 0.5 Mu g/mL (100 Mu L/well) can bind Recombinant Human VEGFR3 with a linear range of 3.92-15.70 ng/mL. |
| Gene Symbol: |
VEGFC |
| Gene ID: |
7424 |
| Uniprot ID: |
VEGFC_HUMAN |
| Immunogen Region: |
Thr103-Arg227 |
| Immunogen: |
Recombinant Human Flt4 ligand/VEGF-C Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Thr103-Arg227) of human VEGF-C/Flt4-L/VRP (Accession #NP_005420.1) fused with a 6×His tag at the C-terminus. |
| Post Translational Modifications | Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3, but only the fully processed form could activate VEGFR-2. VEGF-C first form an antiparallel homodimer linked by disulfide bonds. Before secretion, a cleavage occurs between Arg-227 and Ser-228 producing a heterotetramer. The next extracellular step of the processing removes the N-terminal propeptide. Finally the mature VEGF-C is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions. |
| Function | Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates KDR/VEGFR2 and FLT4/VEGFR3 receptors. |
| Protein Name | Vascular Endothelial Growth Factor CVegf-CFlt4 LigandFlt4-LVascular Endothelial Growth Factor-Related ProteinVrp |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-194313Reactome: R-HSA-195399 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Vascular Endothelial Growth Factor C proteinVegf-C proteinFlt4 Ligand proteinFlt4-L proteinVascular Endothelial Growth Factor-Related Protein proteinVrp proteinVEGFC protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
