Human Flt3 ligand/Flt3L protein (Recombinant) (C-His) (STJP000950)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human Flt3 ligand/Flt3L Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Thr27-Pro185) of human FLT3L/Flt3 ligand/FLT3LG (Accession #NP_001450.2) fused with a 6ΓHis tag at the C-terminu
General Information
| Short Description | Recombinant-Human Flt3 ligand/Flt3L-C-His protein was developed in hek293 cells using the region Thr27-Pro185. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20Β°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity | Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human Flt3 ligand at 2 Mu g/mL (100 Mu L/well) can bind Recombinant Human Flt-3 with a linear range of 0.128-3.97 ng/mL. |
| Determination Method | < 0.1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | FLT3LG |
| Gene ID | 2323 |
| Uniprot ID | FLT3L_HUMAN |
| Immunogen | Recombinant Human Flt3 ligand/Flt3L Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Thr27-Pro185) of human FLT3L/Flt3 ligand/FLT3LG (Accession #NP_001450.2) fused with a 6ΓHis tag at the C-terminu |
| Immunogen Region | Thr27-Pro185 |
| Immunogen Sequence | TQDCSFQHSPISSDFAVKIR ELSDYLLQDYPVTVASNLQD EELCGGLWRLVLAQRWMERL KTVAGSKMQGLLERVNTEIH FVTKCAFQPPPSCLRFVQTN ISRLLQETSEQLVALKPWIT RQNFSRCLELQCQPDSSTLP PPWSPRPLEATAPTAPQPP |
Additional Info
| Function | Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins. Required for the development of B cells, and dendritic cells (DCs). |
| Protein Name | Fms-Related Tyrosine Kinase 3 LigandFlt3 LigandFlt3lSl Cytokine |
| Database Links | Reactome: R-HSA-109704Reactome: R-HSA-1257604Reactome: R-HSA-2219530Reactome: R-HSA-5673001Reactome: R-HSA-6811558Reactome: R-HSA-9607240Reactome: R-HSA-9645135Reactome: R-HSA-9706369Reactome: R-HSA-9706374Reactome: R-HSA-9706377 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: Secreted |
| Alternative Protein Names | Fms-Related Tyrosine Kinase 3 Ligand proteinFlt3 Ligand proteinFlt3l proteinSl Cytokine proteinFLT3LG protein |
Information sourced from Uniprot.org