| Post Translational Modifications | ISGylation prevents ability to interact with the upstream activators of the JNK cascade and inhibits IFNA-induced JNK signaling. Ubiquitination by a SCF-like complex containing ASB2 isoform 1 leads to proteasomal degradation which promotes muscle differentiation. |
| Function | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| Protein Name | Filamin-BFln-BAbp-278Abp-280 HomologActin-Binding-Like ProteinBeta-FilaminFilamin Homolog 1Fh1Filamin-3Thyroid AutoantigenTruncated Actin-Binding ProteinTruncated Abp |
| Database Links | Reactome: R-HSA-1169408 |
| Cellular Localisation | Isoform 1: CytoplasmCell CortexCytoplasmCytoskeletonStress FiberMyofibrilSarcomereZ LineIn Differentiating MyotubesIsoform 1Isoform 2 And Isoform 3 Are Localized Diffusely Throughout The Cytoplasm With Regions Of Enrichment At The Longitudinal Actin Stress FiberIn Differentiated TubesIsoform 1 Is Also Detected Within The Z-LinesIsoform 2: CytoplasmIsoform 3: CytoplasmIsoform 6: CytoplasmPolarized At The Periphery Of Myotubes |
| Alternative Protein Names | Filamin-B proteinFln-B proteinAbp-278 proteinAbp-280 Homolog proteinActin-Binding-Like Protein proteinBeta-Filamin proteinFilamin Homolog 1 proteinFh1 proteinFilamin-3 proteinThyroid Autoantigen proteinTruncated Actin-Binding Protein proteinTruncated Abp proteinFLNB proteinFLN1L proteinFLN3 proteinTABP proteinTAP protein |
Information sourced from Uniprot.org
