Human FKBP12/FKBP1A protein (Recombinant) (His-Tag) (STJP016439)

Name: Human FKBP12/FKBP1A protein (Recombinant) (His-Tag) (STJP016439)
SKU: STJP016439
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostE.coli

ImmunogenHuman

STJP016439

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Short Description	Recombinant-Human FKBP12/FKBP1A-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications	SDS-PAGE/Enzyme Activity
Host	E.coli
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Concentration	1 mg/mL
Formulation	Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 100mM NaCl, 1mM DTT, 10% Glycerol
Storage Instruction	For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Endotoxin	< 1 EU per 1ug of protein (determined by LAL method)
Immunoreactivity	Specific activity is > 800nmol/min/mg, and is defined as the amount of enzyme that cleaves 1nmole of suc-AAPF-pNA per minute at 37C in Tris-HCl pH 8.0 using chymotrypsin.

Gene Symbol	FKBP1A
Gene ID	2280
Uniprot ID	FKB1A_HUMAN
Accession Number	NP_463460.1
Immunogen	Human
Immunogen Region	1-108aa
Immunogen Sequence	MGVQVETISP GDGRTFPKRG QTCVVHYTGM LEDGKKFDSS RDRNKPFKFM LGKQEVIRGW EEGVAQMSVG QRAKLTISPD YAYGATGHPG IIPPHATLVF DVELLKLE

Function	Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Protein Name	Peptidyl-Prolyl Cis-Trans Isomerase Fkbp1a Ppiase Fkbp1a 12 Kda Fk506-Binding Protein 12 Kda Fkbp Fkbp-12 Calstabin-1 Fk506-Binding Protein 1a Fkbp-1a Immunophilin Fkbp12 Rotamase
Database Links	Reactome: R-HSA-166208 Reactome: R-HSA-2025928 Reactome: R-HSA-2173789 Reactome: R-HSA-2173791 Reactome: R-HSA-3656535 Reactome: R-HSA-9679191 Reactome: R-HSA-9692916
Cellular Localisation	Cytoplasm Cytosol Sarcoplasmic Reticulum Membrane Peripheral Membrane Protein Cytoplasmic Side
Alternative Protein Names	Peptidyl-Prolyl Cis-Trans Isomerase Fkbp1a protein Ppiase Fkbp1a protein 12 Kda Fk506-Binding Protein protein 12 Kda Fkbp protein Fkbp-12 protein Calstabin-1 protein Fk506-Binding Protein 1a protein Fkbp-1a protein Immunophilin Fkbp12 protein Rotamase protein FKBP1A protein FKBP1 protein FKBP12 protein

Information sourced from Uniprot.org