| Tissue Specificity | |
| Post Translational Modifications | Ubiquitinated by MARCHF5. |
| Function | Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. May not be essential for the assembly of functional fission complexes and the subsequent membrane scission event. Also mediates peroxisomal fission. May act when the products of fission are directed toward mitochondrial homeostasis, mitophagy, or apoptosis. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. |
| Protein Name | Mitochondrial Fission 1 ProteinFis1 HomologHfis1Tetratricopeptide Repeat Protein 11Tpr Repeat Protein 11 |
| Database Links | Reactome: R-HSA-9603798 |
| Cellular Localisation | Mitochondrion Outer MembraneSingle-Pass Membrane ProteinPeroxisome Membrane |
| Alternative ELISA Names | Mitochondrial Fission 1 Protein ELISA kitFis1 Homolog ELISA kitHfis1 ELISA kitTetratricopeptide Repeat Protein 11 ELISA kitTpr Repeat Protein 11 ELISA kitFIS1 ELISA kitTTC11 ELISA kitCGI-135 ELISA kit |
| output | |
Information sourced from Uniprot.org
