Human FIH-1/HIF-1AN protein (Recombinant) (No-Tag) (STJP019650)

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STJP019650
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human FIH-1/HIF-1AN-No-Tag protein was developed from e.coli and has a target region of No-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0)
Concentration: 1 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: HIF1AN
Gene ID: 55662
Uniprot ID: HIF1N_HUMAN
Immunogen Region: 1-349aa
Accession Number: NP_060372
Immunogen: Human
Immunogen Sequence: MAATAAEAVA SGSGEPREEA GALGPAWDES QLRSYSFPTR PIPRLSQSDP RAEELIENEE PVVLTDTNLV YPALKWDLEY LQENIGNGDF SVYSASTHKF LYYDEKKMAN FQNFKPRSNR EEMKFHEFVE KLQDIQQRGG EERLYLQQTL NDTVGRKIVM DFLGFNWNWI NKQQGKRGWG QLTSNLLLIG MEGNVTPAHY DEQQNFFAQI KGYKRCILFP PDQFECLY
Function Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation.
Protein Name Hypoxia-Inducible Factor 1-Alpha Inhibitor
Factor Inhibiting Hif-1
Fih-1
Hypoxia-Inducible Factor Asparagine Hydroxylase
Database Links Reactome: R-HSA-1234174
Cellular Localisation Nucleus
Cytoplasm
Perinuclear Region
Mainly Cytoplasmic Localization
But Interaction With Notch1 Results In Nuclear Localization And Interaction With Abpa3 Results In Perinuclear Localization In Macrophages
Alternative Protein Names Hypoxia-Inducible Factor 1-Alpha Inhibitor protein
Factor Inhibiting Hif-1 protein
Fih-1 protein
Hypoxia-Inducible Factor Asparagine Hydroxylase protein
HIF1AN protein
FIH1 protein

Information sourced from Uniprot.org

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