Human FGF-19 protein (Recombinant) (His-Tag) (STJP019447)
SPECIFICATIONS
HostHEK293 Cells
ImmunogenHuman
General Information
| Short Description | Recombinant-Human FGF-19-His-Tag protein was developed from hek293 cells and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | HEK293 Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid In 20mM Tris-HCl (pH8.0) containing 0.1M NaCl, 20% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Endotoxin | < 1 EU per 1ug of protein (determined by LAL method) |
Target Information
| Gene Symbol | FGF19 |
| Gene ID | 9965 |
| Uniprot ID | FGF19_HUMAN |
| Accession Number | NP_005108.1 |
| Immunogen | Human |
| Immunogen Region | 23-216aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Expressed in fetal brain, cartilage, retina, and adult gall bladder. |
| Function | Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4. |
| Protein Name | Fibroblast Growth Factor 19Fgf-19 |
| Database Links | Reactome: R-HSA-109704Reactome: R-HSA-1257604Reactome: R-HSA-1307965Reactome: R-HSA-190322Reactome: R-HSA-2219530Reactome: R-HSA-5654228Reactome: R-HSA-5654712Reactome: R-HSA-5654719Reactome: R-HSA-5654720Reactome: R-HSA-5654733Reactome: R-HSA-5673001Reactome: R-HSA-6811558 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Fibroblast Growth Factor 19 proteinFgf-19 proteinFGF19 proteinUNQ334 proteinPRO533 protein |
Information sourced from Uniprot.org