Human FGF-19 protein (Recombinant) (C-His) (STJP001244)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human FGF-19 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Phe27-Lys216) of human FGF-19 (Accession #NP_005108.1) fused with a 6×His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human FGF-19-C-His protein was developed in hek293 cells using the region Phe27-Lys216. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity | Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human FGF19 at 5 Mu g/mL (100 Mu L/well) can bind Recombinant Human FGFR4 with a linear range of 0.9-3.8 Mu g/mL. |
| Determination Method | < 0.1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | FGF19 |
| Gene ID | 9965 |
| Uniprot ID | FGF19_HUMAN |
| Immunogen | Recombinant Human FGF-19 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Phe27-Lys216) of human FGF-19 (Accession #NP_005108.1) fused with a 6×His tag at the C-terminus. |
| Immunogen Region | Phe27-Lys216 |
| Immunogen Sequence | FSDAGPHVHYGWGDPIRLRH LYTSGPHGLSSCFLRIRADG VVDCARGQSAHSLLEIKAVA LRTVAIKGVHSVRYLCMGAD GKMQGLLQYSEEDCAFEEEI RPDGYNVYRSEKHRLPVSLS SAKQRQLYKNRGFLPLSHFL PMLPMVPEEPEDLRGHLESD MFSSPLETDSMDPFGLVTGL EAVRSPSFEK |
Additional Info
| Tissue Specificity | Expressed in fetal brain, cartilage, retina, and adult gall bladder. |
| Function | Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4. |
| Protein Name | Fibroblast Growth Factor 19Fgf-19 |
| Database Links | Reactome: R-HSA-109704Reactome: R-HSA-1257604Reactome: R-HSA-1307965Reactome: R-HSA-190322Reactome: R-HSA-2219530Reactome: R-HSA-5654228Reactome: R-HSA-5654712Reactome: R-HSA-5654719Reactome: R-HSA-5654720Reactome: R-HSA-5654733Reactome: R-HSA-5673001Reactome: R-HSA-6811558 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Fibroblast Growth Factor 19 proteinFgf-19 proteinFGF19 proteinUNQ334 proteinPRO533 protein |
Information sourced from Uniprot.org