| Host: | E.coli |
| Applications: | SDS-PAGE |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human FGF-12-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Formulation: | Liquid in 20mM Tris-HCl buffer (pH 7.5) containing 10% Glycerol, 1mM DTT, 2mM EDTA |
| Concentration: | 1 mg/mL |
| Storage Instruction: | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Endotoxin: | < 1 EU per 1ug of protein (determined by LAL method) |
| Gene Symbol: | FGF12 |
| Gene ID: | 2257 |
| Uniprot ID: | FGF12_HUMAN |
| Immunogen Region: | 1-181aa |
| Accession Number: | AAH22524.1 |
| Immunogen: | Human |
| Immunogen Sequence: | MGSSHHHHHH SSGLVPRGSH MESKEPQLKG IVTRLFSQQG YFLQMHPDGT IDGTKDENSD YTLFNLIPVG LRVVAIQGVK ASLYVAMNGE GYLYSSDVFT PECKFKESVF ENYYVIYSST LYRQQESGRA WFLGLNKEGQ IMKGNRVKKT KPSSHFVPKP IEVCMYREQS LHEIGEKQGR SRKSSGTPTM NGGKVVNQDS T |
| Tissue Specificity | Brain, eye and testis.highly expressed in embryonic retina, olfactory epithelium, olfactory bulb, and in a segmental pattern of the body wall.in adult olfactory bulb, less in cerebellum, deep cerebellar nuclei, cortex and multiple midbrain structures. |
| Function | Involved in nervous system development and function. Involved in the positive regulation of voltage-gated sodium channel activity. Promotes neuronal excitability by elevating the voltage dependence of neuronal sodium channel SCN8A fast inactivation. |
| Protein Name | Fibroblast Growth Factor 12Fgf-12Fibroblast Growth Factor Homologous Factor 1Fhf-1Myocyte-Activating Factor |
| Database Links | Reactome: R-HSA-5576892 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Fibroblast Growth Factor 12 proteinFgf-12 proteinFibroblast Growth Factor Homologous Factor 1 proteinFhf-1 proteinMyocyte-Activating Factor proteinFGF12 proteinFGF12B proteinFHF1 protein |
Information sourced from Uniprot.org