Human FDFT1 protein (Recombinant) (N-His-SUMO) (STJP010051)

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STJP010051
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Covered by St John's Laboratory Guarantee

Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human FDFT1-N-His-SUMO protein was developed from e. coli and has a target region of N-His-SUMO. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: FDFT1
Gene ID: 2222
Uniprot ID: FDFT_HUMAN
Immunogen Region: Met1-Gln283
Immunogen: Homo sapiens (Human)
Function Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene. Proceeds in two distinct steps. In the first half-reaction, two molecules of FPP react to form the stable presqualene diphosphate intermediate (PSQPP), with concomitant release of a proton and a molecule of inorganic diphosphate. In the second half-reaction, PSQPP undergoes heterolysis, isomerization, and reduction with NADPH or NADH to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway.
Protein Name Squalene Synthase
Sqs
Ss
Fpp -Fpp Farnesyltransferase
Farnesyl-Diphosphate Farnesyltransferase
Farnesyl-Diphosphate Farnesyltransferase 1
Database Links Reactome: R-HSA-191273
Reactome: R-HSA-1989781
Reactome: R-HSA-2426168
Cellular Localisation Endoplasmic Reticulum Membrane
Multi-Pass Membrane Protein
Alternative Protein Names Squalene Synthase protein
Sqs protein
Ss protein
Fpp -Fpp Farnesyltransferase protein
Farnesyl-Diphosphate Farnesyltransferase protein
Farnesyl-Diphosphate Farnesyltransferase 1 protein
FDFT1 protein

Information sourced from Uniprot.org

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