Human FCRL2/FCRH2/IRTA4 protein (Recombinant) (C-6His) (STJP020099)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human FCRL2/FCRH2/IRTA4 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Leu20-Asp395) of Human FCRL2/FCRH2/IRTA4 (Accession #NP_110391.2) fused with His at the C-terminus.
General Information
| Short Description | Recombinant-Human FCRL2/FCRH2/IRTA4-C-6His protein was developed in hek293 cells using the region Leu20-Asp395. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.2 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 0.1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | FCRL2 |
| Gene ID | 79368 |
| Uniprot ID | FCRL2_HUMAN |
| Immunogen | Recombinant Human FCRL2/FCRH2/IRTA4 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Leu20-Asp395) of Human FCRL2/FCRH2/IRTA4 (Accession #NP_110391.2) fused with His at the C-terminus. |
| Immunogen Region | Leu20-Asp395 |
| Immunogen Sequence | LTLVAPSSVFEGDSIVLKCQ GEQNWKIQKMAYHKDNKELS VFKKFSDFLIQSAVLSDSGN YFCSTKGQLFLWDKTSNIVK IKVQELFQRPVLTASSFQPI EGGPVSLKCETRLSPQRLDV QLQFCFFRENQVLGSGWSSS PELQISAVWSEDTGSYWCKA ETVTHRIRKQSLQSQIHVQR IPISNVSLEIRAPGGQVTEG QKLILLCSVAGGTGNVTFSW YREATGTSMGKKTQRSLSA |
Additional Info
| Tissue Specificity | Expressed in the secondary lymphoid organs, spleen and lymph node. Expression is limited to the mature B-cell lines. Highly expressed in CD19 and within the mantle zones of the tonsil tissue. Isoform 2 is expressed in the spleen, peripheral blood and bone marrow. Isoform 2 and isoform 4 are expressed in B-cell lines. Preferentially expressed in memory B-cells (at protein level). |
| Post Translational Modifications | Isoform 2 is N- and O-glycosylated, and phosphorylated. |
| Function | May have an regulatory role in normal and neoplastic B cell development. |
| Protein Name | Fc Receptor-Like Protein 2Fcr-Like Protein 2Fcrl2Fc Receptor Homolog 2Fcrh2Ifgp Family Protein 4Immunoglobulin Receptor Translocation-Associated Protein 4Sh2 Domain-Containing Phosphatase Anchor Protein 1Cd Antigen Cd307b |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Fc Receptor-Like Protein 2 proteinFcr-Like Protein 2 proteinFcrl2 proteinFc Receptor Homolog 2 proteinFcrh2 proteinIfgp Family Protein 4 proteinImmunoglobulin Receptor Translocation-Associated Protein 4 proteinSh2 Domain-Containing Phosphatase Anchor Protein 1 proteinCd Antigen Cd307b proteinFCRL2 proteinFCRH2 proteinIFGP4 proteinIRTA4 proteinSPAP1 proteinUNQ9236 proteinPRO31998 protein |
Information sourced from Uniprot.org