• Human Fc-gamma RIII beta/CD16b protein (Recombinant) (C-His) (STJP001060)
  • Human Fc-gamma RIII beta/CD16b protein (Recombinant) (C-His) (STJP001060)
  • Human Fc-gamma RIII beta/CD16b protein (Recombinant) (C-His) (STJP001060)
  • Human Fc-gamma RIII beta/CD16b protein (Recombinant) (C-His) (STJP001060)

Human Fc-gamma RIII beta/CD16b protein (Recombinant) (C-His) (STJP001060)

SKU:
STJP001060

£106.50 - £359.50
Current Stock:
Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 0.1 EU/Mu g of the protein by LAL method.
Immunoreactivity: Measured by its binding ability in a functional ELISA.Immobilized APC anti-human CD16 Antibody at 1 Mu g/mL (25 Mu L/well) can bind Human FCGR3B with a linear range of 0.46-1.16ng/mL.
Gene Symbol: FCGR3B
Gene ID: 2215
Uniprot ID: FCG3B_HUMAN
Immunogen: Recombinant Human Fc-gamma RIII beta/CD16b Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Thr20-Gln208) of human Fc gamma RIIIB/CD16b (Accession #NP_000561.3) fused with a 6×His tag at the C-term
Immunogen Sequence: TEDLPKAVVFLEPQWYSVLE KDSVTLKCQGAYSPEDNSTQ WFHNENLISSQASSYFIDAA TVNDSGEYRCQTNLSTLSDP VQLEVHIGWLLLQAPRWVFK EEDPIHLRCHSWKNTALHKV TYLQNGKDRKYFHHNSDFHI PKATLKDSGSYFCRGLVGSK NVSSETVNITITQGLAVSTI SSFSPPGYQ
Tissue Specificity Expressed specifically by polymorphonuclear leukocytes (neutrophils). Also expressed by stimulated eosinophils.
Post Translational Modifications Glycosylated. Glycosylation plays an inhibitory role in the interaction with IgG3. The soluble form is produced by a proteolytic cleavage.
Function Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.
Protein Name Low Affinity Immunoglobulin Gamma Fc Region Receptor Iii-B
Fc-Gamma Riii-Beta
Cd16-I
Fc-Gamma Riii
Fc-Gamma Riiib
Fcriii
Fcriiib
Fcr-10
Igg Fc Receptor Iii-1
Cd Antigen Cd16b
Database Links Reactome: R-HSA-163125
Reactome: R-HSA-6798695
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Secreted
Secreted After Cleavage
Alternative Protein Names Low Affinity Immunoglobulin Gamma Fc Region Receptor Iii-B protein
Fc-Gamma Riii-Beta protein
Cd16-I protein
Fc-Gamma Riii protein
Fc-Gamma Riiib protein
Fcriii protein
Fcriiib protein
Fcr-10 protein
Igg Fc Receptor Iii-1 protein
Cd Antigen Cd16b protein
FCGR3B protein
CD16B protein
FCG3 protein
FCGR3 protein
IGFR3 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance