Host: |
HEK293 cells |
Reactivity: |
Human |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Recombinant-Human Fc-gamma RIIa/CD32a (H167R)-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications. |
Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation. |
Immunoreactivity: |
Measured by its binding ability in a functional ELISA. Immobilized recombinant human CD32a at 1 Mu g/mL (100 Mu L/well) can bind biotinylated human IgG1 with a linear range of 30-250 ng/mL. |
Gene Symbol: |
FCGR2A |
Gene ID: |
2212 |
Uniprot ID: |
FCG2A_HUMAN |
Immunogen: |
Recombinant Human Fc-gamma RIIa/CD32a (H167R) Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala36-Ile218 (R167) ) of human Fc gamma RIIA/CD32a (Accession #NP_001129691.1) fused with a 6Ă—His tag |
Tissue Specificity | Found on monocytes, neutrophils and eosinophil platelets. |
Post Translational Modifications | Phosphorylated by SRC-type Tyr-kinases such as LYN, BLK, FYN, HCK and SYK. |
Function | Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens. |
Protein Name | Low Affinity Immunoglobulin Gamma Fc Region Receptor Ii-AIgg Fc Receptor Ii-ACdw32Fc-Gamma Rii-AFc-Gamma-RiiaFcrii-ACd Antigen Cd32 |
Database Links | Reactome: R-HSA-2029481Reactome: R-HSA-2029482Reactome: R-HSA-2029485Reactome: R-HSA-6798695Reactome: R-HSA-9664323 |
Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
Alternative Protein Names | Low Affinity Immunoglobulin Gamma Fc Region Receptor Ii-A proteinIgg Fc Receptor Ii-A proteinCdw32 proteinFc-Gamma Rii-A proteinFc-Gamma-Riia proteinFcrii-A proteinCd Antigen Cd32 proteinFCGR2A proteinCD32 proteinFCG2 proteinFCGR2A1 proteinIGFR2 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance