Human FBP1 protein (Recombinant) (C-His) (STJP013149)

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STJP013149-100
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Short Description :Recombinant-Human FBP1-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Applications:ELISA/WB
Host:Mammalian Cells
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation:Unconjugated
Formulation:Supplied as a 0.22 Mu m filtered solution in 20mM Tris-HCl, 200mM NaCl, 1mM DTT, 1mMEDTA, 10% Glycerol, pH 8.0.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin:< 1 EU/µg as determined by LAL test.
Gene Symbol:FBP1
Gene ID:2203
Uniprot ID:F16P1_HUMAN
Immunogen:Homo sapiens (Human)
Immunogen Region:Ala2-Gln338
Function Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity.increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.
Protein Name Fructose-1 -6-Bisphosphatase 1
Fbpase 1
D-Fructose-1 -6-Bisphosphate 1-Phosphohydrolase 1
Liver Fbpase
Database Links Reactome: R-HSA-70263
Cellular Localisation
Alternative Protein Names Fructose-1 -6-Bisphosphatase 1 protein
Fbpase 1 protein
D-Fructose-1 -6-Bisphosphate 1-Phosphohydrolase 1 protein
Liver Fbpase protein
FBP1 protein
FBP protein

Information sourced from Uniprot.org

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