| Applications: | ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.062ng/mL |
| Detection Limit: | 0.156-10ng/mL |
| Short Description : | This FBLIM1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human serum, plasma, tissue homogenates or other biological fluids.. |
| Storage Instruction: | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 3 hrs |
| Gene Symbol: | FBLIM1 |
| Gene ID: | 54751 |
| Uniprot ID: | FBLI1_HUMAN |
| Immunogen Region: | Ready-To-Use |
| Sample Type: | serum, plasma, tissue homogenates or other biological fluids. |
| Tissue Specificity | Isoform 1 and isoform 3 are expressed in heart, kidney, lung, pancreas, placenta and platelets. Isoform 2 is expressed in brain, heart, kidney, lung, pancreas, placenta, skeletal muscle and platelets. |
| Post Translational Modifications | |
| Function | Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion. |
| Protein Name | Filamin-Binding Lim Protein 1 Fblp-1 Migfilin Mitogen-Inducible 2-Interacting Protein Mig2-Interacting Protein |
| Database Links | Reactome: R-HSA-446353 |
| Cellular Localisation | Cell Junction Focal Adhesion Cytoplasm Cytoskeleton Stress Fiber Associated With Actin Stress Fiber At Cell-Ecm Focal Adhesion Sites Isoform 1 And Isoform 3 Are Recruited And Localized At Actin Stress Fibers And Clustered At Cell-Emc Adhesion Sites Through Interaction With Fermt2 Isoform 2 Is Localized At Actin Stress Fibers |
| Alternative ELISA Names | Filamin-Binding Lim Protein 1 ELISA kit Fblp-1 ELISA kit Migfilin ELISA kit Mitogen-Inducible 2-Interacting Protein ELISA kit Mig2-Interacting Protein ELISA kit FBLIM1 ELISA kit FBLP1 ELISA kit |
| output |
Information sourced from Uniprot.org