Tissue Specificity | Highest levels of expression are detected in muscle and adipose tissue small, intermediate levels in small intestine, and barely detectable in liver. Expressed in brain gray matter. |
Post Translational Modifications | |
Function | Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport at the plasma membrane. Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Probably involved in fatty acid transport across the blood barrier. |
Protein Name | Long-Chain Fatty Acid Transport Protein 1Arachidonate--Coa LigaseFatty Acid Transport Protein 1Fatp-1Long-Chain-Fatty-Acid--Coa LigaseSolute Carrier Family 27 Member 1Very Long-Chain Acyl-Coa Synthetase |
Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-804914 |
Cellular Localisation | Cell MembraneSingle-Pass Membrane ProteinEndomembrane SystemCytoplasmPlasma Membrane And Intracellular MembranesAt Least In AdipocytesIn AdipocytesBut Not MyocytesInsulin Via The Mtorc1 Signaling Pathway Induces A Rapid Translocation Of Slc27a1 From Intracellular Compartments To The Plasma MembraneParalleled By Increased Lcfa UptakeInsulin-Dependent Translocation From The Cytoplasm To The Cell Membrane Is Regulated By Eprs1Predominantly Cytoplasmic In Myocytes |
Alternative ELISA Names | Long-Chain Fatty Acid Transport Protein 1 ELISA kitArachidonate--Coa Ligase ELISA kitFatty Acid Transport Protein 1 ELISA kitFatp-1 ELISA kitLong-Chain-Fatty-Acid--Coa Ligase ELISA kitSolute Carrier Family 27 Member 1 ELISA kitVery Long-Chain Acyl-Coa Synthetase ELISA kitSLC27A1 ELISA kitACSVL5 ELISA kitFATP1 ELISA kit |
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Information sourced from Uniprot.org