| Applications: | ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.116ng/mL |
| Detection Limit: | 0.312-20ng/mL |
| Short Description : | This FATP1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human serum, plasma, tissue homogenates or other biological fluids.. |
| Storage Instruction: | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 4.5 hrs |
| Gene Symbol: | SLC27A1 |
| Gene ID: | 376497 |
| Uniprot ID: | S27A1_HUMAN |
| Sample Type: | serum, plasma, tissue homogenates or other biological fluids. |
| Tissue Specificity | Highest levels of expression are detected in muscle and adipose tissue small, intermediate levels in small intestine, and barely detectable in liver. Expressed in brain gray matter. |
| Post Translational Modifications | |
| Function | Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport at the plasma membrane. Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Probably involved in fatty acid transport across the blood barrier. |
| Protein Name | Long-Chain Fatty Acid Transport Protein 1 Arachidonate--Coa Ligase Fatty Acid Transport Protein 1 Fatp-1 Long-Chain-Fatty-Acid--Coa Ligase Solute Carrier Family 27 Member 1 Very Long-Chain Acyl-Coa Synthetase |
| Database Links | Reactome: R-HSA-1989781 Reactome: R-HSA-804914 |
| Cellular Localisation | Cell Membrane Single-Pass Membrane Protein Endomembrane System Cytoplasm Plasma Membrane And Intracellular Membranes At Least In Adipocytes In Adipocytes But Not Myocytes Insulin Via The Mtorc1 Signaling Pathway Induces A Rapid Translocation Of Slc27a1 From Intracellular Compartments To The Plasma Membrane Paralleled By Increased Lcfa Uptake Insulin-Dependent Translocation From The Cytoplasm To The Cell Membrane Is Regulated By Eprs1 Predominantly Cytoplasmic In Myocytes |
| Alternative ELISA Names | Long-Chain Fatty Acid Transport Protein 1 ELISA kit Arachidonate--Coa Ligase ELISA kit Fatty Acid Transport Protein 1 ELISA kit Fatp-1 ELISA kit Long-Chain-Fatty-Acid--Coa Ligase ELISA kit Solute Carrier Family 27 Member 1 ELISA kit Very Long-Chain Acyl-Coa Synthetase ELISA kit SLC27A1 ELISA kit ACSVL5 ELISA kit FATP1 ELISA kit |
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Information sourced from Uniprot.org