Human Fascin protein (Recombinant) (His-Tag) (STJP016802)

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STJP016802
£134.50 - £738.50
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human Fascin-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 20% Glycerol, 2mM DTT, 100mM NaCl
Concentration: 1 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: FSCN1
Gene ID: 6624
Uniprot ID: FSCN1_HUMAN
Immunogen Region: 1-493aa
Accession Number: NP_003079
Immunogen: Human
Immunogen Sequence: MTANGTAEAV QIQFGLINCG NKYLTAEAFG FKVNASASSL KKKQIWTLEQ PPDEAGSAAV CLRSHLGRYL AADKDGNVTC EREVPGPDCR FLIVAHDDGR WSLQSEAHRR YFGGTEDRLS CFAQTVSPAE KWSVHIAMHP QVNIYSVTRK RYAHLSARPA DEIAVDRDVP WGVDSLITLA FQDQRYSVQT ADHRFLRHDG RLVARP
Tissue Specificity Ubiquitous.
Post Translational Modifications Phosphorylation at Ser-39 inhibits actin-binding. Phosphorylation is required for the reorganization of the actin cytoskeleton in response to NGF.
Function Actin-binding protein that contains 2 major actin binding sites. Organizes filamentous actin into parallel bundles. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration. Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF.
Protein Name Fascin
55 Kda Actin-Bundling Protein
Singed-Like Protein
P55
Database Links Reactome: R-HSA-6785807
Cellular Localisation Cytoplasm
Cytosol
Cell Cortex
Cytoskeleton
Stress Fiber
Cell Projection
Filopodium
Invadopodium
Microvillus
Cell Junction
Colocalized With Rufy3 And F-Actin At Filipodia Of The Axonal Growth Cone
Colocalized With Dbn1 And F-Actin At The Transitional Domain Of The Axonal Growth Cone
Alternative Protein Names Fascin protein
55 Kda Actin-Bundling Protein protein
Singed-Like Protein protein
P55 protein
FSCN1 protein
FAN1 protein
HSN protein
SNL protein

Information sourced from Uniprot.org

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