Human FANCM protein (Recombinant) (N-His) (STJP011021)

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STJP011021
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human FANCM-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: FANCM
Gene ID: 57697
Uniprot ID: FANCM_HUMAN
Immunogen Region: Ser281-His620
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylated.hyperphosphorylated in response to genotoxic stress.
Function DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX. In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates. In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA.
Protein Name Fanconi Anemia Group M Protein
Protein Facm
Atp-Dependent Rna Helicase Fancm
Fanconi Anemia-Associated Polypeptide Of 250 Kda
Faap250
Protein Hef Ortholog
Database Links Reactome: R-HSA-6783310
Reactome: R-HSA-9833482
Cellular Localisation Nucleus
Alternative Protein Names Fanconi Anemia Group M Protein protein
Protein Facm protein
Atp-Dependent Rna Helicase Fancm protein
Fanconi Anemia-Associated Polypeptide Of 250 Kda protein
Faap250 protein
Protein Hef Ortholog protein
FANCM protein
KIAA1596 protein

Information sourced from Uniprot.org

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