Human FADD protein (Recombinant) (N-His) (STJP005294)

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STJP005294
€410.63 - €1,796.88
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human FADD-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: FADD
Gene ID: 8772
Uniprot ID: FADD_HUMAN
Immunogen Region: Ser12-Glu206
Immunogen: Homo sapiens (Human)
Post Translational Modifications (Microbial infection) Glycosylated at Arg-117 by enteropathogenic E.coli protein NleB1, C.rodentium protein NleB and S.typhimurium protein Ssek1: arginine GlcNAcylation prevents recruitment of caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors.
Function Apoptotic adapter molecule that recruits caspases CASP8 or CASP10 to the activated FAS/CD95 or TNFRSF1A/TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. Active CASP8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.
Protein Name Fas-Associated Death Domain Protein
Fas-Associating Death Domain-Containing Protein
Growth-Inhibiting Gene 3 Protein
Mediator Of Receptor Induced Toxicity
Database Links Reactome: R-HSA-140534
Reactome: R-HSA-2562578
Reactome: R-HSA-3371378
Reactome: R-HSA-5213460
Reactome: R-HSA-5218900
Reactome: R-HSA-5357786
Reactome: R-HSA-5357905
Reactome: R-HSA-5675482
Reactome: R-HSA-69416
Reactome: R-HSA-75157
Reactome: R-HSA-75158
Reactome: R-HSA-9013957
Reactome: R-HSA-933543
Reactome: R-HSA-9693928
Alternative Protein Names Fas-Associated Death Domain Protein protein
Fas-Associating Death Domain-Containing Protein protein
Growth-Inhibiting Gene 3 Protein protein
Mediator Of Receptor Induced Toxicity protein
FADD protein
MORT1 protein
GIG3 protein

Information sourced from Uniprot.org