| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human FADD-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | FADD |
| Gene ID: | 8772 |
| Uniprot ID: | FADD_HUMAN |
| Immunogen Region: | Ser12-Glu206 |
| Immunogen: | Homo sapiens (Human) |
| Post Translational Modifications | (Microbial infection) Glycosylated at Arg-117 by enteropathogenic E.coli protein NleB1, C.rodentium protein NleB and S.typhimurium protein Ssek1: arginine GlcNAcylation prevents recruitment of caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. |
| Function | Apoptotic adapter molecule that recruits caspases CASP8 or CASP10 to the activated FAS/CD95 or TNFRSF1A/TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. Active CASP8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. |
| Protein Name | Fas-Associated Death Domain ProteinFas-Associating Death Domain-Containing ProteinGrowth-Inhibiting Gene 3 ProteinMediator Of Receptor Induced Toxicity |
| Database Links | Reactome: R-HSA-140534Reactome: R-HSA-2562578Reactome: R-HSA-3371378Reactome: R-HSA-5213460Reactome: R-HSA-5218900Reactome: R-HSA-5357786Reactome: R-HSA-5357905Reactome: R-HSA-5675482Reactome: R-HSA-69416Reactome: R-HSA-75157Reactome: R-HSA-75158Reactome: R-HSA-9013957Reactome: R-HSA-933543Reactome: R-HSA-9693928 |
| Alternative Protein Names | Fas-Associated Death Domain Protein proteinFas-Associating Death Domain-Containing Protein proteinGrowth-Inhibiting Gene 3 Protein proteinMediator Of Receptor Induced Toxicity proteinFADD proteinMORT1 proteinGIG3 protein |
Information sourced from Uniprot.org
