Human EWSR1 protein (Recombinant) (N-His-SUMO) (STJP007990)

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STJP007990
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human EWSR1-N-His-SUMO protein was developed from e. coli and has a target region of N-His-SUMO. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: EWSR1
Gene ID: 2130
Uniprot ID: EWS_HUMAN
Immunogen Region: Asp353-Arg446
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylated.calmodulin-binding inhibits phosphorylation of Ser-266. Highly methylated on arginine residues. Methylation is mediated by PRMT1 and, at lower level by PRMT8.
Function Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.
Protein Name Rna-Binding Protein Ews
Ews Oncogene
Ewing Sarcoma Breakpoint Region 1 Protein
Cellular Localisation Nucleus
Cytoplasm
Cell Membrane
Relocates From Cytoplasm To Ribosomes Upon Ptk2b/Fak2 Activation
Alternative Protein Names Rna-Binding Protein Ews protein
Ews Oncogene protein
Ewing Sarcoma Breakpoint Region 1 Protein protein
EWSR1 protein
EWS protein

Information sourced from Uniprot.org

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