Human ETS1 protein (Recombinant) (N-His) (STJP009600)

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STJP009600
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human ETS1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: ETS1
Gene ID: 2113
Uniprot ID: ETS1_HUMAN
Immunogen Region: Gly302-Glu441
Immunogen: Homo sapiens (Human)
Post Translational Modifications Sumoylated on Lys-15 and Lys-227, preferentially with SUMO2.which inhibits transcriptional activity. Ubiquitinated.which induces proteasomal degradation. Phosphorylation at Ser-251, Ser-282 and Ser-285 by CaMK2/CaMKII in response to calcium signaling decreases affinity for DNA: an increasing number of phosphoserines causes DNA-binding to become progressively weaker.
Function Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion. Isoform Ets-1 p27: Acts as a dominant-negative for isoform c-ETS-1A.
Protein Name Protein C-Ets-1
P54
Database Links Reactome: R-HSA-2559585
Cellular Localisation Nucleus
Cytoplasm
Delocalizes From Nucleus To Cytoplasm When Coexpressed With Isoform Ets-1 P27
Alternative Protein Names Protein C-Ets-1 protein
P54 protein
ETS1 protein
EWSR2 protein

Information sourced from Uniprot.org

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